Showing posts with label REVERSING. Show all posts
Showing posts with label REVERSING. Show all posts

Can you prevent diabetes with intermittent fasting?

Yes! Intermittent fasting can improve insulin sensitivity, pancreatic response to blood sugars, and even prevent prediabetes from turning into diabetes.
Every person is a unique individual with different metabolism, so there is not just one treatment for type 2 diabetes. Intermittent fasting has been around for a long time and has shown over many studies to have a number of benefits, especially in preventing diabetes.
In the most current study results, which included eight men with prediabetes, it was found that those who followed early time-restricted feeding — where all calories for the day are consumed by mid-afternoon and within eight hours or less — had improvements in insulin sensitivity and pancreatic response to elevated blood glucose, compared with those who ate meals over a 12-hour period, even when eating the same number of calories. The findings also revealed an association between the shorter, earlier eating pattern and a significant reduction in blood pressure, oxidative stress, and evening appetite levels.
For this study at the Pennington Biomedical Research Center, the results showed that eating all of one’s meals by mid-afternoon and fasting the rest of the day improves blood sugar control, blood pressure and oxidative stress, even when people don’t change what they eat.
“This is the first study in humans that shows consuming all of your calories in a six-hour period provides metabolic advantages compared to eating the exact same amount over 12 hours or more, even if you don’t lose weight,” said Dr. Eric Ravussin, associate executive director of Pennington Biomedical, director of the Nutrition Obesity Research Center, and one of the study’s co-authors.
The data also indicate that our feeding regimen has to be synchronized with the body’s circadian rhythm and biological clock.
Dr. Courtney Peterson, an adjunct assistant professor at Pennington Biomedical and an assistant professor at the University of Alabama at Birmingham, was the primary investigator on the study.
The research is important because it shows for the first time in humans that the benefits of intermittent fasting are not solely due to eating less. Practicing intermittent fasting has intrinsic benefits regardless of what you eat. Also, the study shows that eating early in the day may be a particularly beneficial form of intermittent fasting.
Peterson hopes that the research will also raise awareness of the role of the body’s internal biological clock — called the circadian system — in health.
We know that eating at night is bad for your metabolism. Our bodies are optimized to do certain things at certain times of the day and eating in sync with our circadian rhythms seems to improve our health in multiple ways. For instance, our body’s ability to keep our blood sugar under control is better in the morning than it is in the afternoon and the evening, so it makes sense to eat most of our food in the morning and early afternoon.
Previous studies showed intermittent fasting improves metabolism and health. However, researchers didn’t know whether these effects are simply because people ate less and lost weight.
They decided to conduct the first highly controlled study to determine whether the benefits of intermittent fasting are solely due to eating less. The study was also the first to test a form of intermittent fasting called early time-restricted feeding, or eTRF in humans. Early time-restricted feeding involves combining time-restricted feeding — a type of intermittent fasting where people eat in an 8-hour or shorter period each day — with eating early in the day to be in alignment with the body’s circadian rhythms in metabolism. It is tantamount to eating dinner in the mid-afternoon and then fasting for the rest of the day.
In the study, eight men with prediabetes tried following eTRF and eating at typical American meal times for five weeks each. On the eTRF schedule, the men each started breakfast between 6:30-8:30 am each morning, finished eating six hours later, and then fasted for the rest of the day — about 18 hours. Everyone finished dinner no later than 3 p.m. By contrast, on the typical American schedule, they ate their meals spread across a 12-hour period. The men ate the same foods on each schedule, and the researchers carefully monitored the men to make sure that they ate at the correct times and only ate the food that the researchers gave them.
The researchers found that eTRF improved insulin sensitivity, which reflects how quickly cells can take up blood sugar, and it also improved their pancreases’ ability to respond to rising blood sugar levels. The researchers also found that eTRF dramatically lowered the men’s blood pressure, as well as their oxidative stress levels and their appetite levels in the evening.
These findings could lead to better ways to help prevent type 2 diabetes and hypertension.
- diabetesincontrol.com

How weight loss can reverse type 2 diabetes


Many diabetics are reversing their type 2 diabetes by losing weight. Many of them achieve this by spending up to five months on a low-calorie diet of soups and shakes to cause massive weight loss.
One of then is Isobel Murray, 65, who had weighed 15 stone, lost over four stone (25kg) and no longer needs diabetes pills. 
She says: "I've got my life back. I don't look at myself as a diabetic at all.
"You have to be fired up, you have to be prepared, but anybody can do it if you feel strongly enough."
The charity Diabetes UK says the trial is a landmark and has the potential to help millions of patients.
Isobel, from Largs in North Ayrshire, was one of 298 people on the trial.
Her blood sugar levels were too high, and she got her medication increased every time she went to the doctors.
So, she adopted the all-liquid diet for 17 weeks - giving up cooking and shopping. She even ate apart from her husband, Jim.
Instead, she had four liquid meals a day.
It is hardly Masterchef - a sachet of powder is stirred in water to make a soup or shake. They contain about 200 calories, but also the right balance of nutrients.
Isobel said this is easy as "you don't have to think about what you eat".
Once the weight has been lost, dieticians then help patients introduce healthy, solid meals.
"Eating normal food is the hardest bit," says Isobel.
The trial results, presented at the International Diabetes Federation, showed:
  • 46% of patients who started the trial were in remission a year later
  • 86% who lost 15kg (2st 5lb) or more put their type 2 diabetes into remission
  • Only 4% went into remission with the best treatments currently used
According to Prof Roy Taylor, from Newcastle University: "It's a real watershed moment.
"Before we started this line of work, doctors and specialists regarded type 2 as irreversible.
"But if we grasp the nettle and get people out of their dangerous state, they can get remission of diabetes."
One negative thing about this is that doctors are not calling this a cure. They said if the weight goes return, then the diabetes will return.
Isobel said she will make sure she maintained her current weight so as to keep diabetes at bay. And so far, she has kept the weight off for two years.

The next question is : Why does losing weight work for diabetes?

Answer
Body fat that build around the pancreas causes stress to the beta cells in the organ that controls blood sugar levels. This will make the pancreas to stop producing enough of the hormone insulin, which definately causes blood sugar levels to rise out of control.
So when you lose the fat or diet, you loses the fat, and then the pancreas works properly again.
However, as good as the trial look, it is thought having type 2 diabetes for very long periods of time may cause irreversible damage because the trial was only carried out on patients having the disease for 6 years and below.
Prof Mike Lean, from Glasgow University, admitted: "It's hugely exciting."
"We now have clear evidence that weight loss of 10-15kg is enough to turn this disease around.
It is estimated that 1 in 11 adults worldwide has diabetes, mostly type 2.
Some of the complications of  uncontrolled sugar levels are damage throughout the body, which cab lead to organ failure, blindness and limb amputations.
Diabetes is very expensive to treat as treating the disease costs the UK's NHS about £10bn a year.
According to Dr Elizabeth Robertson, the director of research at Diabetes UK: "[The trial has] the potential to transform the lives of millions of people.
"The trial is ongoing, so that we can understand the long-term effects of an approach like this."

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