Showing posts with label Type 2 Diabetes. Show all posts
Showing posts with label Type 2 Diabetes. Show all posts
Healthy weight and exercise can reduce risk of type 2 diabetes
While obesity and type 2 diabetes are twins, research shows that eating a healthy diet and getting regular exercise can greatly help reduce the risk of gaining weight and even put type 2 diabetes into remission.
According to Professor Schulze: "Our findings highlight the importance of preventing the development of metabolic diseases. They suggest that even individuals in good metabolic health may benefit from early behavioural management to improve their diet and increased physical activity in order to guard against progression to poor metabolic health."
In addition Benedict Jephcote, Editor of Diabetes.co.uk, said: "The take-home message from this study is that those who are at a healthy weight, and metabolically healthy too, are in the best position to avoid heart disease. This can be achieved by eat real, unprocessed foods and prioritising non-starchy vegetables over starchy foods.
"In 2015, we launched our Low Carb Program which helps people to choose a way of eating that can help people achieve better metabolic health. The program has allowed people to achieve great success and many people have found it to be so successful that they no longer need some of their diabetes medication."
Diabetes drug metformin might curb the development of multidrug resistance in vitro in breast melanoma cells - Research
MDR could be delayed, avoided, or reversed using metformin.
Terra Arnason, Ph.D. an associate professor and clinician scientist in the division and institution of medication and colleagues led the be taught. Their findings had been released within the journal PLOS ONE.
Multidrug resistance (MDR) happens when a couple of cancers develop resistance to chemotherapy medicines. MDR is a giant aspect in the failure of many forms of chemotherapy, and it's typically a terminal event. It influences participants with blood cancers and stable tumors, including those with breast melanoma.
How and why melanoma cells come to be resistant to medications has remained a fundamental query in melanoma research. The answer would furnish capabilities ambitions to avert and reverse resistance to healing.
Persons who increase resistance to one agent frequently advance resistance to many, as a result being often called "a multi- drug resistance."
Antiproliferative effect on melanoma cells
Arnason and group aimed to examine the effect of metformin on MDR when used at the side of the main therapy.
Metformin is a drug used to deal with type 2 diabetes when weight loss program and physical activities have not helped to manage blood sugar levels. Metformin helps to slash blood sugar by making improvements to the way in which the physique manages insulin.
In prior study, metformin has been shown to have an antiproliferative effect on tumor cells, which means that the drug inhibits the growth and unfold of cancer cells.
Humans with type 2 diabetes and melanoma who take metformin were said to have a 31 percentage reduction in the occurrence of recent cancers. Additionally, metformin has been advised to improve all-rationale survival in these with breast cancer.
The team deliberate to evaluate the mechanisms that facilitate metformin's antiproliferative affect and experiment whether utilising metformin pretreatment might benefit or interfere with MDR cancer.
They used the generally studied MCF7 breast melanoma telephone strains and demonstrated them for resistance to the chemotherapy drug doxorubicin in an effort to examine the antiproliferative outcomes of metformin.
Resistance reversed after metformin use
Arnason and colleagues observed that metformin had an antiproliferative effect on MCF7, including the cells that have been immune to doxorubicin.
The progress of drug resistance was delayed or prevented in cells that have been pretreated with metformin. And, experiments conducted in cells cultures and mouse models of aggressive breast melanoma uncovered that MDR used to be reversed after its onset through metformin use.
Together, the findings reveal the potential for metformin to be utilized as a remedy to hinder or reverse MDR. The authors write:
"now we have demonstrated that metformin monotherapy has an antiproliferative result on a couple of mobilephone strains, including those selected for resistance to doxorubicin, in a dose-stylish manner."
"The effect can also be observed," the study authors conclude, "when metformin is utilized in combo with other anticancer treatments in breast melanoma cells."
"Our findings are regular with the developing literature base demonstrating metformin's potential to reduce the development of tumor cells in vitro."
Future work by the team will involve analyzing cancer cells over many months to become aware of whether the effect of metformin is short- or long-time period.
Can type 2 diabetes turn to type 1 diabetes?
Type1 and type 2 diabetes have many elements in fashioned, including problems managing blood glucose phases. But the two conditions are certain, and one does not turn out to the other over time.
Listed here, are the differences between the 2 types of diabetes and why they do not alternate.
Type1 vs. type2 diabetes
character with diabetes checking their blood sugar
although people with diabetes all have blood sugar issues, type1 and a couple of are rather one-of-a-kind disorders.
Despite the fact that they cause similar symptoms, type 1 and type 2 diabetes are distinct problems. Type 1 diabetes, generally known as juvenile diabetes, is almost always identified in childhood or early maturity.
Type 1 diabetes is an autoimmune disease, this means that the body attacks its own healthy cells. This method prevents the pancreas from making insulin, the hormone that helps the physique control its blood glucose phases.
Persons with type 1 diabetes have to take synthetic insulin for the rest of their lives. Way of life alterations is not going to reverse juvenile diabetes.
Type 2 diabetes is the most original type of diabetes. Usually identified in adulthood, this form of diabetes interferes with the body's capability to produce and use insulin. Not like juvenile diabetes, tradition causes, similar to inactiveness or weight problems, can expand the probability of setting up type 2 diabetes.
In some circumstances, the symptoms of type 2 diabetes may be managed with way of life changes, together with dropping pounds, eating a healthful weight-reduction plan, and exercising more commonly.
Like different autoimmune issues, researchers don't comprehend what motives type 1 diabetes. Each environmental and genetic causes may have roles. For illustration, a individual with a gene for type 1 diabetes would now not have symptoms unless some thing within the environment prompts that gene.
Once type 1 diabetes develops, the body continues attacking the pancreas unless the entire beta cells are destroyed. These beta cells are most important for producing insulin. It's thus unattainable for folks with type 1 diabetes to make insulin.
Each genetic and environmental explanations additionally play a role in type 2 diabetes. Nevertheless, type 2 diabetes is extra closely related to culture.
Some humans with type 2 diabetes can reduce the severity of symptoms and even do away with them with healthy culture changes, even as others remain insulin resistant even after making alterations.
Insulin is a hormone that allows the body to use glucose from meals. When the body does no longer make enough insulin, or when it can not respond properly to insulin, blood glucose rises. Blood glucose is a measure of how much sugar is in the blood.
Both types of diabetes may also be managed with insulin injections, but form 2 diabetes can also be managed with oral medications and subculture alterations.
Can type 2 diabetes become type 1 diabetes?
It's unimaginable for type 2 diabetes to turn out to be type 1.
It isn't feasible for type 2 diabetes to become type 1 diabetes.
Nonetheless, it's feasible for a individual who's at first identified with type 2 diabetes to be diagnosed with type 1 diabetes later.
Type 2 diabetes is the most common type of diabetes, so a health care professional would initially believe an grownup with diabetes has type 2.
This can be in particular authentic if the person is obese or has different danger motives for diabetes, equivalent to a sedentary way of life.
It is feasible for a person with type 1 diabetes to be misdiagnosed with type 2 diabetes.
Although wonderful, type 1 diabetes can show up in adulthood.
A person identified with type 2 diabetes who later receives a diagnosis of type 1 don't have experienced a transformation in their diabetes however was likely misdiagnosed previous.
To correctly diagnose the type of diabetes a man or woman has, a doctor will participate in a few blood glucose tests.
They may additionally do blood tests to check for antibodies that attack insulin or beta cells in the pancreas. The presence of these antibodies commonly shows whether a man or woman has type 1 diabetes.
Insulin dependency
insulin levels being monitored
it's important for men and women with diabetes to observe their insulin.
Men and women with type 1 diabetes may just must make tradition alterations, such as averting high glucose meals. Lifestyle alterations by self, nevertheless, is not going to reverse or preclude type 1 diabetes. Because of this people with type 1 diabetes are insulin dependent, and the situation is oftentimes known as insulin based diabetes.
Men and women with type 1 diabetes need to intently reveal their blood glucose phases. Even with everyday monitoring and commonplace insulin injections, they are going to boost dangerously high blood glucose. When this happens, they would want extra insulin or emergency hospital treatment.
People with type 1 diabetes have to take insulin for the rest of their lives. Individuals with type 2 diabetes will best need insulin if other therapies fail.
Type 2 diabetes is most often a progressive disease. Insulin can also be used in combination with other medicines to optimize blood sugar manage.
Type 1 and type 2 diabetes are designated forms that don't alternate into one another . Nevertheless, insulin could also be used to treat both sort. While insulin is the one therapy on hand for type 1 diabetes, it is also utilized in type 2 diabetes if additional evolved levels or if different cures don't work.
The signs of each forms of diabetes is also subtle at first. However, diabetes that is left untreated can cause long-term problems and generally become life-threatening.
The primary signs of diabetes could incorporate accelerated thirst, improved daytime and hour of darkness urination, and unexplained weight loss. Any person with these signs should have their blood sugar demonstrated through a health practitioner. Testing is principally crucial in households with a historical past of diabetes.
Healthy meals can help people with type 2 diabetes
Thousands of studies carried out across 42 years were analysed to see which treatment yielded the best results and helped people with type 2 diabetes change their behaviour.
Researchers from the University of British Columbia (UBC) found the intervention which garnered the best results was when healthy diet were provided and participants had regular contact and help from dieticans.
According to Kevin Cradock, the study's first author and an Irish Research Council postgraduate scholar at the National University of Ireland (NUI) Galway: "Changing the food environment is one of the keys to treating type 2 diabetes. Before we change the food environment we need to look carefully at what it is and how it affects us."
Feedback on behaviour, solving problems and comparing themselves to others are three major techniques found by the research team that help people change their attitudes to food
Professor Heather Gainsforth, an assistant professor at UBC Okanagan's School of Health and Exercise Sciences, remarked: "Without any support, behaviour change efforts can quickly fall apart. We need to be thinking about a better way to support people with diabetes.
"It may seem impractical to provide food and control the food environment. However, we need to examine the viability of providing healthy meals at the beginning of a program, followed by instruction and feedback as to how to choose, shop for and prepare these foods. Gradually, this approach may support people to prepare healthy meals independently."
How weight loss can reverse type 2 diabetes
One of then is Isobel Murray, 65, who had weighed 15 stone, lost over four stone (25kg) and no longer needs diabetes pills.
She says: "I've got my life back. I don't look at myself as a diabetic at all.
"You have to be fired up, you have to be prepared, but anybody can do it if you feel strongly enough."
The charity Diabetes UK says the trial is a landmark and has the potential to help millions of patients.
Isobel, from Largs in North Ayrshire, was one of 298 people on the trial.
Her blood sugar levels were too high, and she got her medication increased every time she went to the doctors.
So, she adopted the all-liquid diet for 17 weeks - giving up cooking and shopping. She even ate apart from her husband, Jim.
Instead, she had four liquid meals a day.
It is hardly Masterchef - a sachet of powder is stirred in water to make a soup or shake. They contain about 200 calories, but also the right balance of nutrients.
Isobel said this is easy as "you don't have to think about what you eat".
Once the weight has been lost, dieticians then help patients introduce healthy, solid meals.
"Eating normal food is the hardest bit," says Isobel.
The trial results, presented at the International Diabetes Federation, showed:
- 46% of patients who started the trial were in remission a year later
- 86% who lost 15kg (2st 5lb) or more put their type 2 diabetes into remission
- Only 4% went into remission with the best treatments currently used
According to Prof Roy Taylor, from Newcastle University: "It's a real watershed moment.
"Before we started this line of work, doctors and specialists regarded type 2 as irreversible.
"But if we grasp the nettle and get people out of their dangerous state, they can get remission of diabetes."
One negative thing about this is that doctors are not calling this a cure. They said if the weight goes return, then the diabetes will return.
Isobel said she will make sure she maintained her current weight so as to keep diabetes at bay. And so far, she has kept the weight off for two years.
The next question is : Why does losing weight work for diabetes?
Answer
Body fat that build around the pancreas causes stress to the beta cells in the organ that controls blood sugar levels. This will make the pancreas to stop producing enough of the hormone insulin, which definately causes blood sugar levels to rise out of control.
So when you lose the fat or diet, you loses the fat, and then the pancreas works properly again.
However, as good as the trial look, it is thought having type 2 diabetes for very long periods of time may cause irreversible damage because the trial was only carried out on patients having the disease for 6 years and below.
Prof Mike Lean, from Glasgow University, admitted: "It's hugely exciting."
"We now have clear evidence that weight loss of 10-15kg is enough to turn this disease around.
It is estimated that 1 in 11 adults worldwide has diabetes, mostly type 2.
Some of the complications of uncontrolled sugar levels are damage throughout the body, which cab lead to organ failure, blindness and limb amputations.
Diabetes is very expensive to treat as treating the disease costs the UK's NHS about £10bn a year.
According to Dr Elizabeth Robertson, the director of research at Diabetes UK: "[The trial has] the potential to transform the lives of millions of people.
"The trial is ongoing, so that we can understand the long-term effects of an approach like this."
6 Reasons Why Children Develop Diabetes Than Before
Children are now developing diabetes type 2 at an alarming rate. This type of diabetes was considered as an adult diabetes before. But now both young and old including the children are susceptible to type 2 diabetes.
If children had diabetes before, it will be type 1 because 99% of children diabetes then are type 1. That is why type 2 diabetes was considered an adult disease.
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